Technology

Problem

Many laboratories, pilot lines, and early-stage biomanufacturing teams still depend on imported standard enzymes that are not optimized for their specific process conditions.

For difficult enzyme systems, the main challenge is not only obtaining a gene sequence. Functional production requires host selection, expression optimization, metal/cofactor availability, protein purification, enzyme assay design, and product-level validation.

This creates a gap between academic enzyme discovery and practical industrial use. 

Solution

Korenzyme aims to bridge this gap by providing customized enzyme development and microbial biocatalyst validation services.

We support enzyme-based projects from candidate selection to functional testing, including gene design, microbial expression, purification, activity assays, stability evaluation, and GC-based product analysis.

Our goal is to help research teams and companies move faster from enzyme concept to validated biocatalyst. 

Technology

Our platform combines enzyme biochemistry, microbial host engineering, and analytical validation.

Core capabilities include:

• Enzyme candidate screening and selection

• Heterologous gene expression in microbial hosts

• Microbial host engineering and troubleshooting

• Protein purification and biochemical characterization

• Enzyme activity and stability assays

• GC-based product analysis

• Adaptive laboratory evolution and omics-supported interpretation

Our first technology direction focuses on metal-dependent formate dehydrogenase systems, especially enzymes related to CO2/formate conversion and NADH-dependent biocatalysis. 

Applications

Korenzyme focuses on enzyme and biocatalyst solutions for:

• CO2/formate-related biocatalysis

• Cofactor regeneration systems

• Sustainable biochemical production

• Enzyme-assisted carbon utilization research

• Customized enzyme production for laboratories and pilot lines

• Early-stage validation of microbial biomanufacturing processes

The long-term vision is to support low-carbon chemical production through practical, validated enzyme platforms.